4-(Chloromethyl)pyridine hydrochloride

  • Name: 4-(Chloromethyl)pyridine hydrochloride
  • CAS: 1822-51-1
  • Purity: 99%
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Details

High Quality Chinese Manufacturer supply 1822-51-1 4-(Chloromethyl)pyridine hydrochloride

  • Molecular Formula: C6H6ClN.HCl
  • Molecular Weight: 164.034
  • Appearance/Colour: White crystalline powder 
  • Vapor Pressure: 0.257mmHg at 25°C 
  • Melting Point: 166-173 °C(lit.) 
  • Refractive Index: 1.53 
  • Boiling Point: 212 °C at 760 mmHg 
  • Flash Point: 102 °C 
  • PSA： 12.89000 
  • Density: 1.156g/cm3 
  • LogP: 2.62240 

4-(Chloromethyl)pyridine hydrochloride(Cas 1822-51-1) Usage

Purification Methods

Purify it by recrystallisation from EtOH or EtOH/dry Et2O. It melts between 171o and 175o, and the clear melt resolidifies on further heating at 190o and turns red to black at 280o but does not melt again. The picrate-hydrochloride (prepared in EtOH) has m 146-147o. The free base is an oil. [Mosher & Tessieri J Am Chem Soc 73 4925 1951, Beilstein 20 III/IV 2752.]

InChI:InChI=1/C6H6ClN/c7-5-6-1-3-8-4-2-6/h1-4H,5H2

1822-51-1 Relevant articles

A 4 - chloromethyl pyridine hydrochloride synthetic method

-

Paragraph 0016; 0019; 0023; 0024; 0028; 0029; 0033, (2019/06/05)

The invention belongs to the field of or...

Tetrazolylhydrazides as selective fragment-like inhibitors of the JumonjiC-domain-containing histone demethylase KDM4A

Rüger, Nicole,Roatsch, Martin,Emmrich, Thomas,Franz, Henriette,Schüle, Roland,Jung, Manfred,Link, Andreas

supporting information, p. 1875 - 1883 (2015/11/10)

The JumonjiC-domain-containing histone d...

Facile and Selective Synthesis of Chloromethylpyridines and Chloropyridines Using Diphosgene/Triphosgene

Narendar,Gangadasu,Ramesh, Ch.,Raju, B. China,Rao, V. Jayathirtha

, p. 1097 - 1103 (2007/10/03)

Diphosgene and triphosgene in the presen...

Process for producing arylsulfenyl halide

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Page/Page column 13, (2010/11/29)

A process for producing a compound of th...

1822-51-1 Process route

4-methylpyridine-1-oxide
1003-67-4

4-methylpyridine-1-oxide

2-chloro-4-picoline
3678-62-4

2-chloro-4-picoline

4-picolylchloride hydrochloride
1822-51-1

4-picolylchloride hydrochloride

Conditions
Conditions Yield
With diisopropylamine; trichloromethyl chloroformate; In dichloromethane; at -40 - 20 ℃;
pyridine-4-methanol
586-95-8

pyridine-4-methanol

4-picolylchloride hydrochloride
1822-51-1

4-picolylchloride hydrochloride

Conditions
Conditions Yield
With thionyl chloride; In acetonitrile; at 50 ℃; for 1h;
100%
With thionyl chloride; In acetonitrile;
With thionyl chloride; In dichloromethane;
With thionyl chloride; In methanol;
26.9 g

1822-51-1 Upstream products

  • 1003-67-4
    1003-67-4

    4-methylpyridine-1-oxide

  • 586-95-8
    586-95-8

    pyridine-4-methanol

  • 121-44-8
    121-44-8

    triethylamine

  • 63608-12-8
    63608-12-8

    4-(phenoxymethyl)pyridine

1822-51-1 Downstream products

  • 102547-80-8
    102547-80-8

    4-((allyloxy)methyl)pyridine

  • 70199-60-9
    70199-60-9

    4-(methoxymethyl)pyridine

  • 62369-32-8
    62369-32-8

    4-(ethoxymethyl)pyridine

  • 63608-12-8
    63608-12-8

    4-(phenoxymethyl)pyridine

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