demeclocycline

  • Name: demeclocycline
  • CAS: 127-33-3
  • Purity: 99%
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1.What is the demeclocycline ?

Demeclocycline, a chlortetracycline analogue produced by a mutagenised strain of Streptomyces aureofaciens, was first isolated in 1957. Like all tetracyclines, demeclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis. Demeclocycline has been extensively cited in the literature with over 800 references relating almost exclusively to in vivo use.

Demeclocycline
127-33-3

Demeclocycline

Conditions
Conditions Yield
von Cu-Chelat;
Demeclocycline
127-33-3

Demeclocycline

sancycline
808-26-4,2696-12-0,15964-02-0,39105-46-9

sancycline

Conditions
Conditions Yield
With 10% rhodium on carbon; hydrogen; toluene-4-sulfonic acid; In methanol; at 20 ℃; for 15h; under 11251.1 - 18751.9 Torr; Reagent/catalyst; Pressure; Solvent; Autoclave;
88%

2.What is the CAS number for demeclocycline ?

The CAS number of demeclocycline is 127-33-3.

More information of demeclocycline 127-33-3 are:

CAS?Number

127-33-3

Density

1.75g/cm3

Melting Point

176°C (rough estimate)

Boiling Point

684.5°Cat760mmHg

Flash Point

367.8°C

Vapor Pressure

1.02E-26mmHg at 25°C

Refractive Index

1.6000 (estimate)

PSA

181.62000

LogP

0.96520

Pka

4.50±1.00(Predicted)

3.What are another words for demeclocycline ?

Synonyms?for?demeclocycline 127-33-3:2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-(8CI); 2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,[4S-(4a,4aa,5aa,6b,12aa)]-; 6-Demethyl-7-chlorotetracycline;6-Demethyl-7-chlortetracycline; 6-Demethylchlorotetracycline;6-Demethylchlortetracycline;7-Chloro-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide;7-Chloro-6-demethyltetracycline; Bioterciclin; Chlortetracycline, 6-demethyl-;DMCT; DMCT (antibiotic); Deganol; Demeclocycline; Demeclor;Demethylchlorotetracycline; Demethylchlortetracyclin;Demethylchlortetracycline; Demetraclin; Diuciclin; Elkamicina; Ledermycin;Mexocine; Novotriclina; Perciclina; Periciclina; RP 10192; Sumaclina;Tri-demethylchlortetracycline

4.What is the molecular formula of demeclocycline?

The chemical formula of ?demeclocycline is?C21H21 Cl N2 O8 which containing 21 Carbon atoms,21 Hydrogen atoms,1 Chlorine atoms,2 Nitrogen atoms and 8 Oxygen atoms,and the molecular weight of??demeclocycline?is 464.859.

5.What is demeclocycline (127-33-3) used for?

Demeclocycline, a chlortetracycline analogue, is an antibiotic derived from a mutagenized strain of Streptomyces aureofaciens. It was first isolated in 1957 and is characterized by its broad-spectrum antibacterial and antiprotozoan activity. Demeclocycline works by binding to the 30S and 50S ribosomal subunits, thereby blocking protein synthesis. It is known for its slower excretion rate, which allows for the maintenance of effective blood levels for a longer duration.

InChI:InChI=1/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1

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